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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM3
All Species:
36.97
Human Site:
S599
Identified Species:
58.1
UniProt:
P25205
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25205
NP_002379.2
808
90981
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Chimpanzee
Pan troglodytes
XP_001151750
808
90957
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Rhesus Macaque
Macaca mulatta
XP_001106966
808
90990
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Dog
Lupus familis
XP_538960
916
102667
S707
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Cat
Felis silvestris
Mouse
Mus musculus
P25206
812
91528
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Rat
Rattus norvegicus
XP_001070728
813
91641
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMN2
812
91233
S600
E
E
Y
S
S
L
R
S
Q
N
Q
M
N
S
D
Frog
Xenopus laevis
Q7ZXZ0
806
90528
N599
E
E
Y
T
R
L
R
N
Q
D
Q
M
S
T
D
Zebra Danio
Brachydanio rerio
NP_997732
807
90502
N598
E
E
Y
S
R
L
R
N
Q
E
Q
L
G
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511048
819
90900
S593
N
E
Y
S
R
L
R
S
Q
E
A
V
E
T
D
Honey Bee
Apis mellifera
XP_625020
811
91329
S597
A
E
Y
S
K
L
R
S
E
E
S
I
D
S
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
T556
D
I
A
G
V
P
K
T
A
T
T
D
S
D
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
I562
V
K
F
L
K
K
Y
I
H
Y
A
K
N
L
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
I572
T
D
E
A
S
E
R
I
A
E
A
Y
A
D
L
Baker's Yeast
Sacchar. cerevisiae
P24279
971
107499
Y683
I
N
V
I
V
K
N
Y
T
D
L
R
N
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
86
N.A.
92.9
93.3
N.A.
N.A.
81.4
80.1
75.9
N.A.
62.5
62.7
30.8
N.A.
Protein Similarity:
100
99.8
100
87.2
N.A.
96.6
97
N.A.
N.A.
92
90.7
88.1
N.A.
80
78.6
49.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
73.3
73.3
66.6
N.A.
60
60
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
86.6
93.3
86.6
N.A.
86.6
86.6
33.3
N.A.
Percent
Protein Identity:
N.A.
47.6
N.A.
49.3
39.8
N.A.
Protein Similarity:
N.A.
66
N.A.
68.1
54.7
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
40
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
7
0
0
0
0
14
0
20
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
0
0
0
0
0
54
0
7
7
20
80
% D
% Glu:
60
74
7
0
0
7
0
0
7
27
0
0
7
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
7
0
7
0
0
0
14
0
0
0
7
0
0
7
% I
% Lys:
0
7
0
0
14
14
7
0
0
0
0
7
0
0
0
% K
% Leu:
0
0
0
7
0
74
0
0
0
0
7
7
0
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% M
% Asn:
7
7
0
0
0
0
7
14
0
7
0
0
20
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
67
0
20
0
0
0
0
% Q
% Arg:
0
0
0
0
60
0
80
0
0
0
0
7
0
0
0
% R
% Ser:
0
0
0
67
14
0
0
60
0
0
47
0
54
60
0
% S
% Thr:
7
0
0
7
0
0
0
7
7
7
7
0
0
14
0
% T
% Val:
7
0
7
0
14
0
0
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
74
0
0
0
7
7
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _